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TY  - JOUR
AU  - Hassan, I. M. 
AU  - Saidu, B. 
PY  - 2024/07/20
Y2  - 2026/08/29
TI  - Effect of Biochemical Constituents of Detarium senegalensis (root) and Eucalyptus camaldulensis (leaf) mixed Methanolic Extracts on Trypanosome brucei-brucei using Mice Model.
JF  - Nigerian Journal of Animal Production
JA  - NJAP
VL  - 
IS  - 
SE  - Articles
DO  - 10.51791/njap.vi.6951
UR  - https://www.njap.org.ng/index.php/njap/article/view/6951
SP  - 24 - 31
AB  - &lt;p&gt;&lt;span class=&quot;fontstyle0&quot;&gt;Medicinal plants are considered to be of great importance to human because they contain active constituents which can be used to treat different diseases. Methanol extracts of &lt;/span&gt;&lt;span class=&quot;fontstyle2&quot;&gt;Detarium senegalensis&lt;/span&gt;&lt;span class=&quot;fontstyle0&quot;&gt;(root) and &lt;/span&gt;&lt;span class=&quot;fontstyle2&quot;&gt;Eucalyptus camaldulensis &lt;/span&gt;&lt;span class=&quot;fontstyle0&quot;&gt;(leaf) were screened for trypanocidal activity. Mice infected with &lt;/span&gt;&lt;span class=&quot;fontstyle2&quot;&gt;Trypanosoma brucei-brucei &lt;/span&gt;&lt;span class=&quot;fontstyle0&quot;&gt;were treated with methanol extracts of root of D. &lt;/span&gt;&lt;span class=&quot;fontstyle2&quot;&gt;senegalensis &lt;/span&gt;&lt;span class=&quot;fontstyle0&quot;&gt;and leaf of &lt;/span&gt;&lt;span class=&quot;fontstyle2&quot;&gt;E&lt;/span&gt;&lt;span class=&quot;fontstyle0&quot;&gt;. &lt;/span&gt;&lt;span class=&quot;fontstyle2&quot;&gt;camaldulensis&lt;/span&gt;&lt;span class=&quot;fontstyle0&quot;&gt;. The combination of the extracts in different ratios (1:1,2:1,3:1,1:0 and 0:1) were administered intraperitoneally at a combined dose level of 200mg/Kg body weight/day respectively. Parasitemia was found to increase in all animals with a short relapse and an increase that proceeded till death, except for the ones treated with 2:1(group B) and 0:1(group E) which survived for 26days and 30days respectively. In the repeat screening with 2:1 and 0:1 doses, parasites were cleared from the blood but resurfaced two days later while treatment was on. Only animals treated with 0:1 dose survived for 19 days. This study indicates the possibility of exploiting &lt;/span&gt;&lt;span class=&quot;fontstyle2&quot;&gt;Eucalyptus &lt;/span&gt;&lt;span class=&quot;fontstyle3&quot;&gt;camaldulens &lt;/span&gt;&lt;span class=&quot;fontstyle0&quot;&gt;for the treatment of Trypanosomiasis since its activity was more pronounced.&lt;/span&gt; &lt;/p&gt;
ER  -