DOSE RESPONSE AND AMELIORATIVE EFFECTS OF RESVERATROL ON TRYPANOSOMOSIS-INDUCED REPRODUCTIVE TOXICITY IN DIMINAZENE ACETURATE TREATED TRYPANOSOMA BRUCEI INFECTED MALE DOGS

Abstract

The study was done to assess the dose response and ameliorative effects of resveratrol on trypanosomosis induced testicular changes in diminazene aceturate (DA) treated Trypanosoma brucei infected male dogs. Thirty male dogs were used for the study and were assigned into six groups (n=5). Group A was infected with T. brucei, not treated with (DA) and not supplemented with resveratrol. Group B was presupplemented with resveratrol (50 mg/kg) for 7 days, Infected with T. brucei and treated with DA (7 mg/kg). Group C was presupplemented with resveratrol (100 mg/kg) for 7 days, infected with T. brucei and treated with DA (7 mg/kg). Group D was presupplemented with resveratrol (200 mg/kg) for 7 days, infected with T. brucei and treated with DA (7 mg/kg). Groups B, C and D were postsupplemented with 50, 100 and 200 mg/kg of resveratrol for 14 days respectively. Group E was infected with T. brucei and treated with DA (7 mg/kg). Group F was the control There were significant decreases (p<0.05) in the parasitaemia level and rectal temperature of dogs in group C when compared to other supplemented groups. There were significant increases (p<0.05) testosterone level, testicular weight and epididymal sperm reserve of dogs in group C when compared to other supplemented groups, DA alone and the infected untreated group. In conclusion, this study indicated that resveratrol at the dose of 100 mg/kg may constitute a promising compound for the amelioration of male reproductive toxicity in DA treated Trypanosoma infected male dogs